Related Trials
The innovative design and pragmatic features of Dial-Mag have been adopted from related previous large-scale trials including MyTEMP and RESOLVE. Experience gained through these trials has guided the Dial-Mag Trial through conception, design, and implementation, and allowed us to expand our trial population across four provinces.
The Major outcomes with personalized dialysate TEMPerature (MyTEMP) trial
The MyTEMP Trial
MyTEMP, a pragmatic trial conducted over 4 years in 84 hemodialysis centres across Ontario from 2017 to 2021, tested the effect of randomizing hemodialysis centers to provide:
- a personalized temperature-reduced protocol of 0.5°C to 0.9°C below the patient’s predialysis body temperature vs
- a standard dialysis temperature protocol of 36.5°C.
Click here to read the protocol, statistical analysis plan, or final results.
Resolve
The RESOLVE trial is an ongoing collaboration with The George Institute for Global Health in Australia. This multi-national trial involves more than 300 hemodialysis centres worldwide, and investigates whether treatment with a dialysate sodium concentration of 137 mmol/L, rather than 140 mmol/L, reduces cardiovascular events and death in hemodialysis patients.
Click here for more information.
Future Trials
Our team is always looking for new questions to answers with innovative research methods. We work with international research teams to conduct high-quality research and improve healthcare and the lives of patients. If you have an idea for a trial or would like to know more, please Contact Us.